Leading infectious disease expert Dr. Anthony Fauci was recently asked who he’d want to play him on Saturday Night Live, he remarked Brad Pitt. That casting became a reality last night as the superstar embodied Fauci in the show’s cold open. Watch above as Pitt also sent Fauci a message out of character.

Pitt wasn’t the only celebrity to make a surprise appearance. Former SNL cast member Brad Pitt joined Pete Davidson for this quarantine song.

And Miley Cyrus delivered a stirring rendition of Pink Floyd’s “Wish You Were Here.”

Charles Barkley and DJ Khaled also showed up for the fan-favorite skit “What Up With That.”